PD134308, a selective antagonist of cholecystokinin type B receptor, enhances the analgesic effect of morphine and synergistically interacts with intrathecal galanin to depress spinal nociceptive reflexes.

The effects of systemic PD134308 [0.1-3 mg/kg; an antagonist of the cholecystokinin (CCK) type B receptor], morphine, and intrathecal (i.t.) galanin (GAL) on the excitability of the spinal nociceptive flexor reflex and in the hot plate test were examined in rats. PD134308 caused a weak naloxone-reve...

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Autores principales: Wiesenfeld-Hallin, Z, Xu, X J, Hughes, J, Horwell, D C, Hökfelt, T
Formato: Artigo
Lenguaje:Inglês
Publicado: 1990
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Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC54692/
https://ncbi.nlm.nih.gov/pubmed/1698290
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