Multiscale model predicts increasing focal adhesion size with decreasing stiffness in fibrous matrices

We describe a multiscale model that incorporates force-dependent mechanical plasticity induced by interfiber cross-link breakage and stiffness-dependent cellular contractility to predict focal adhesion (FA) growth and mechanosensing in fibrous extracellular matrices (ECMs). The model predicts that F...

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Bibliografiske detaljer
Udgivet i:Proc Natl Acad Sci U S A
Main Authors: Cao, Xuan, Ban, Ehsan, Baker, Brendon M., Lin, Yuan, Burdick, Jason A., Chen, Christopher S., Shenoy, Vivek B.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2017
Fag:
PNAS Plus
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5468675/
https://ncbi.nlm.nih.gov/pubmed/28468803
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1620486114
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