A Chemomechanical Model of Matrix and Nuclear Rigidity Regulation of Focal Adhesion Size

In this work, a chemomechanical model describing the growth dynamics of cell-matrix adhesion structures (i.e., focal adhesions (FAs)) is developed. We show that there are three regimes for FA evolution depending on their size. Specifically, nascent adhesions with initial lengths below a critical val...

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Publicat a:Biophys J
Autors principals: Cao, Xuan, Lin, Yuan, Driscoll, Tristian P., Franco-Barraza, Janusz, Cukierman, Edna, Mauck, Robert L., Shenoy, Vivek B.
Format: Artigo
Idioma:Inglês
Publicat: The Biophysical Society 2015
Matèries:
Cell Biophysics
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4643201/
https://ncbi.nlm.nih.gov/pubmed/26536258
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2015.08.048
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