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Angular measurements of the dynein ring reveal a stepping mechanism dependent on a flexible stalk

The force-generating mechanism of dynein differs from the force-generating mechanisms of other cytoskeletal motors. To examine the structural dynamics of dynein’s stepping mechanism in real time, we used polarized total internal reflection fluorescence microscopy with nanometer accuracy localization...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Lippert, Lisa G., Dadosh, Tali, Hadden, Jodi A., Karnawat, Vishakha, Diroll, Benjamin T., Murray, Christopher B., Holzbaur, Erika L. F., Schulten, Klaus, Reck-Peterson, Samara L., Goldman, Yale E.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5468668/
https://ncbi.nlm.nih.gov/pubmed/28533393
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1620149114
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