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TRPM2 promotes neurotoxin MPP(+)/MPTP-induced cell death

In neurons, Ca(2+) is essential for a variety of physiological processes that regulate gene transcription to neuronal growth and their survival. 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) and 1-methyl-4-phenylpyridinium ions (MPP(+)), are potent neurotoxins that selectively destroys the dop...

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Detalhes bibliográficos
Publicado no:Mol Neurobiol
Main Authors: Sun, Yuyang, Sukumaran, Pramod, Selvaraj, Senthil, Cilz, Nicholas I., Schaar, Anne, Lei, Saobo, Singh, Brij B
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5468501/
https://ncbi.nlm.nih.gov/pubmed/27957685
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s12035-016-0338-9
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