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A tiered, Bayesian approach to estimating of population variability for regulatory decision-making

Characterizing human variability in susceptibility to chemical toxicity is a critical issue in regulatory decision-making, but is usually addressed by a default 10-fold safety/uncertainty factor. Feasibility of population-based in vitro experimental approaches to more accurately estimate human varia...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Veröffentlicht in:ALTEX
Hauptverfasser: Chiu, Weihsueh A., Wright, Fred A., Rusyn, Ivan
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2016
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5468494/
https://ncbi.nlm.nih.gov/pubmed/27960008
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.14573/altex.1608251
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