Loss of fibronectin from the aged stem cell niche affects the regenerative capacity of skeletal muscle in mice

Age-related changes in the niche have long been postulated to impair the function of somatic stem cells. Here we demonstrate that the aged stem cell niche in skeletal muscle contains substantially reduced levels of fibronectin (FN), leading to detrimental consequences for the function and maintenanc...

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Publié dans:Nat Med
Auteurs principaux: Lukjanenko, Laura, Jung, M Juliane, Hegde, Nagabhooshan, Perruisseau-Carrier, Claire, Migliavacca, Eugenia, Rozo, Michelle, Karaz, Sonia, Jacot, Guillaume, Schmidt, Manuel, Li, Liangji, Metairon, Sylviane, Raymond, Frederic, Lee, Umji, Sizzano, Federico, Wilson, David H, Dumont, Nicolas A, Palini, Alessio, Fässler, Reinhard, Steiner, Pascal, Descombes, Patrick, Rudnicki, Michael A, Fan, Chen-Ming, von Maltzahn, Julia, Feige, Jerome N, Bentzinger, C Florian
Format: Artigo
Langue:Inglês
Publié: 2016
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5467443/
https://ncbi.nlm.nih.gov/pubmed/27376579
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nm.4126
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