IL-21-mediated reversal of NK cell exhaustion facilitates anti-tumour immunity in MHC class I-deficient tumours

During cancer immunoediting, loss of major histocompatibility complex class I (MHC-I) in neoplasm contributes to the evasion of tumours from host immune system. Recent studies have demonstrated that most natural killer (NK) cells that are found in advanced cancers are defective, releasing the malign...

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Publicado no:Nat Commun
Main Authors: Seo, Hyungseok, Jeon, Insu, Kim, Byung-Seok, Park, Myunghwan, Bae, Eun-Ah, Song, Boyeong, Koh, Choong-Hyun, Shin, Kwang-Soo, Kim, Il-Kyu, Choi, Kiyoung, Oh, Taegwon, Min, Jiyoun, Min, Byung Soh, Han, Yoon Dae, Kang, Suk-Jo, Shin, Sang Joon, Chung, Yeonseok, Kang, Chang-Yuil
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5467212/
https://ncbi.nlm.nih.gov/pubmed/28585539
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms15776
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