The Serotonin Receptor 6 Antagonist Idalopirdine and Acetylcholinesterase Inhibitor Donepezil Have Synergistic Effects on Brain Activity—A Functional MRI Study in the Awake Rat

The 5-HT(6) receptor is a promising target for cognitive disorders, in particular for Alzheimer's disease (AD) and other CNS disorders. The high-affinity and selective 5-HT(6) receptor antagonist idalopirdine (Lu AE58054) is currently in development for mild-moderate AD as adjunct therapy to ac...

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Detalhes bibliográficos
Publicado no:Front Pharmacol
Main Authors: Ferris, Craig F., Kulkarni, Praveen, Yee, Jason R., Nedelman, Mark, de Jong, Inge E. M.
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2017
Assuntos:
Pharmacology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5467007/
https://ncbi.nlm.nih.gov/pubmed/28659792
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2017.00279
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