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Selective inhibition of p97 by chlorinated analogues of dehydrocurvularin()

The ATPase p97 is a ubiquitin targeted segregase that uses the energy of ATP binding and hydrolysis to extract ubiquitylated substrates from biological membranes, from other proteins, or from protein complexes to carry out myriad tasks in eukaryotes. Increased p97 activity has been linked to a poor...

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Bibliografiska uppgifter
I publikationen:Org Biomol Chem
Huvudupphovsmän: Tillotson, Joseph, Bashyal, Bharat P., Kang, MinJin, Shi, Taoda, De La Cruz, Fabian, Leslie Gunatilaka, A. A., Chapman, Eli
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2016
Ämnen:
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC5466822/
https://ncbi.nlm.nih.gov/pubmed/27223265
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c6ob00560h
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