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Selective inhibition of p97 by chlorinated analogues of dehydrocurvularin()
The ATPase p97 is a ubiquitin targeted segregase that uses the energy of ATP binding and hydrolysis to extract ubiquitylated substrates from biological membranes, from other proteins, or from protein complexes to carry out myriad tasks in eukaryotes. Increased p97 activity has been linked to a poor...
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| Published in: | Org Biomol Chem |
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| Main Authors: | , , , , , , |
| Format: | Artigo |
| Language: | Inglês |
| Published: |
2016
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5466822/ https://ncbi.nlm.nih.gov/pubmed/27223265 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c6ob00560h |
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