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Activation of α(1A)‐adrenoceptors desensitizes the rat aorta response to phenylephrine through a neuronal NOS pathway, a mechanism lost with ageing

BACKGROUND AND PURPOSE: A NO‐mediated desensitization of vasoconstrictor responses evoked by stimulation of α(1)‐adrenoceptors has been reported in different vessels. We investigated the involvement of each α(1)‐adrenoceptor subtype and constitutive NOS isoforms and the influence of ageing and hyper...

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發表在:Br J Pharmacol
Main Authors: Arce, Cristina, Vicente, Diana, Segura, Vanessa, Flacco, Nicla, Montó, Fermi, Almenar, Luis, Agüero, Jaime, Rueda, Joaquín, Jiménez‐Altayó, Francesc, Vila, Elisabet, Noguera, Maria Antonia, D'Ocon, Pilar, Ivorra, Maria Dolores
格式: Artigo
語言:Inglês
出版: John Wiley and Sons Inc. 2017
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC5466529/
https://ncbi.nlm.nih.gov/pubmed/28369791
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.13800
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