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Activation of α(1A)‐adrenoceptors desensitizes the rat aorta response to phenylephrine through a neuronal NOS pathway, a mechanism lost with ageing
BACKGROUND AND PURPOSE: A NO‐mediated desensitization of vasoconstrictor responses evoked by stimulation of α(1)‐adrenoceptors has been reported in different vessels. We investigated the involvement of each α(1)‐adrenoceptor subtype and constitutive NOS isoforms and the influence of ageing and hyper...
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發表在: | Br J Pharmacol |
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Main Authors: | , , , , , , , , , , , , |
格式: | Artigo |
語言: | Inglês |
出版: |
John Wiley and Sons Inc.
2017
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主題: | |
在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5466529/ https://ncbi.nlm.nih.gov/pubmed/28369791 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.13800 |
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