Activation of α(1A)‐adrenoceptors desensitizes the rat aorta response to phenylephrine through a neuronal NOS pathway, a mechanism lost with ageing

BACKGROUND AND PURPOSE: A NO‐mediated desensitization of vasoconstrictor responses evoked by stimulation of α(1)‐adrenoceptors has been reported in different vessels. We investigated the involvement of each α(1)‐adrenoceptor subtype and constitutive NOS isoforms and the influence of ageing and hyper...

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Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Br J Pharmacol
Egile Nagusiak: Arce, Cristina, Vicente, Diana, Segura, Vanessa, Flacco, Nicla, Montó, Fermi, Almenar, Luis, Agüero, Jaime, Rueda, Joaquín, Jiménez‐Altayó, Francesc, Vila, Elisabet, Noguera, Maria Antonia, D'Ocon, Pilar, Ivorra, Maria Dolores
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: John Wiley and Sons Inc. 2017
Gaiak:
Research Papers
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC5466529/
https://ncbi.nlm.nih.gov/pubmed/28369791
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.13800
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