Activation of α(1A)‐adrenoceptors desensitizes the rat aorta response to phenylephrine through a neuronal NOS pathway, a mechanism lost with ageing

BACKGROUND AND PURPOSE: A NO‐mediated desensitization of vasoconstrictor responses evoked by stimulation of α(1)‐adrenoceptors has been reported in different vessels. We investigated the involvement of each α(1)‐adrenoceptor subtype and constitutive NOS isoforms and the influence of ageing and hyper...

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Detaylı Bibliyografya
Yayımlandı:Br J Pharmacol
Asıl Yazarlar: Arce, Cristina, Vicente, Diana, Segura, Vanessa, Flacco, Nicla, Montó, Fermi, Almenar, Luis, Agüero, Jaime, Rueda, Joaquín, Jiménez‐Altayó, Francesc, Vila, Elisabet, Noguera, Maria Antonia, D'Ocon, Pilar, Ivorra, Maria Dolores
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: John Wiley and Sons Inc. 2017
Konular:
Research Papers
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC5466529/
https://ncbi.nlm.nih.gov/pubmed/28369791
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.13800
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