Activation of α(1A)‐adrenoceptors desensitizes the rat aorta response to phenylephrine through a neuronal NOS pathway, a mechanism lost with ageing

BACKGROUND AND PURPOSE: A NO‐mediated desensitization of vasoconstrictor responses evoked by stimulation of α(1)‐adrenoceptors has been reported in different vessels. We investigated the involvement of each α(1)‐adrenoceptor subtype and constitutive NOS isoforms and the influence of ageing and hyper...

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Publicado en:Br J Pharmacol
Autores principales: Arce, Cristina, Vicente, Diana, Segura, Vanessa, Flacco, Nicla, Montó, Fermi, Almenar, Luis, Agüero, Jaime, Rueda, Joaquín, Jiménez‐Altayó, Francesc, Vila, Elisabet, Noguera, Maria Antonia, D'Ocon, Pilar, Ivorra, Maria Dolores
Formato: Artigo
Lenguaje:Inglês
Publicado: John Wiley and Sons Inc. 2017
Materias:
Research Papers
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5466529/
https://ncbi.nlm.nih.gov/pubmed/28369791
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.13800
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