Ethical and Clinical Safety Considerations in the Design of an Effectiveness Trial: A Comparison of Buprenorphine versus Naltrexone Treatment for Opioid Dependence

We examine ethical challenges encountered in the design of an effectiveness trial (CTN-0051; X:BOT), comparing sublingual buprenorphine-naloxone (BUP-NX), an established treatment for opioid dependence, to the newer extended-release injectable naltrexone (XR-NTX). Ethical issues surrounded: 1) Known...

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Publicado en:Contemp Clin Trials
Autores principales: Nunes, Edward V., Lee, Joshua D, Sisti, Dominic, Segal, Andrea, Caplan, Arthur, Fishman, Marc, Bailey, Genie, Brigham, Gregory, Novo, Patricia, Farkas, Sarah, Rotrosen, John
Formato: Artigo
Lenguaje:Inglês
Publicado: 2016
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5466164/
https://ncbi.nlm.nih.gov/pubmed/27687743
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cct.2016.09.006
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