Rapid Detection and Quantitation of BRAF Mutations in Hairy Cell Leukemia Using a Sensitive Pyrosequencing Assay

BRAF proto-oncogene is an important mediator of cell proliferation and survival signals via the RAS-RAF-MEK-ERK signaling pathway. BRAF p.V600E mutation was recently described as a molecular marker of hairy cell leukemia (HCL). We developed and validated a pyrosequencing-based approach that covers B...

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Detalhes bibliográficos
Publicado no:Am J Clin Pathol
Main Authors: Verma, Shalini, Greaves, Wesley O., Ravandi, Farhad, Reddy, Neelima, Bueso-Ramos, Carlos E., O’Brien, Susan, Thomas, Deborah A., Kantarjian, Hagop, Medeiros, L. Jeffrey, Luthra, Rajyalakshmi, Patel, Keyur P.
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5465956/
https://ncbi.nlm.nih.gov/pubmed/22706871
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1309/AJCPL0OPXI9LZITV
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