In vitro evaluation of dihydropyridine-3-carbonitriles as potential cytotoxic agents through PIM-1 protein kinase inhibition

PIM-1 protein kinase inhibitor belongs to a novel class of serine/threonine kinases. As PIM-1 is overexpressed in cancer cells and possesses oncogenic functions, its inhibition provides a new option in cancer therapy. In this study, in vitro inhibitory effects of seven analogues of 1, 2-dihydropyrid...

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Bibliographic Details
Published in:Res Pharm Sci
Main Authors: Abnous, Khalil, Manavi, Hesam, Mehri, Soghra, Alibolandi, Mona, Kamali, Hossein, Ghandadi, Morteza, Hadizadeh, Farzin
Format: Artigo
Language:Inglês
Published: Medknow Publications & Media Pvt Ltd 2017
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Original Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5465828/
https://ncbi.nlm.nih.gov/pubmed/28626477
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4103/1735-5362.207200
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