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Genetic Analyses of DNA-Binding Mutants in the Catalytic Core Domain of Human Immunodeficiency Virus Type 1 Integrase

The catalytic core domain (CCD) of human immunodeficiency virus type 1 (HIV-1) integrase (IN) harbors the enzyme active site and binds viral and chromosomal DNA during integration. Thirty-five CCD mutant viruses were constructed, paying particular attention to conserved residues in the Phe(139)-Gln(...

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Bibliografski detalji
Glavni autori: Lu, Richard, Limón, Ana, Ghory, Hina Z., Engelman, Alan
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology 2005
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC546573/
https://ncbi.nlm.nih.gov/pubmed/15681450
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.79.4.2493-2505.2005
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