Genetic Analyses of DNA-Binding Mutants in the Catalytic Core Domain of Human Immunodeficiency Virus Type 1 Integrase

The catalytic core domain (CCD) of human immunodeficiency virus type 1 (HIV-1) integrase (IN) harbors the enzyme active site and binds viral and chromosomal DNA during integration. Thirty-five CCD mutant viruses were constructed, paying particular attention to conserved residues in the Phe(139)-Gln(...

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Detalhes bibliográficos

Publicado no:	J Virol
Principais autores:	Lu, Richard, Limón, Ana, Ghory, Hina Z., Engelman, Alan
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Microbiology (ASM) 2005
Assuntos:	Replication
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC546573/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/15681450/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/JVI.79.4.2493-2505.2005
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