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Disease-associated extracellular loop mutations in the adhesion G protein-coupled receptor G1 (ADGRG1; GPR56) differentially regulate downstream signaling

Mutations to the adhesion G protein-coupled receptor ADGRG1 (G1; also known as GPR56) underlie the neurological disorder bilateral frontoparietal polymicrogyria. Disease-associated mutations in G1 studied to date are believed to induce complete loss of receptor function through disruption of either...

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Bibliografiske detaljer
Udgivet i:J Biol Chem
Main Authors: Kishore, Ayush, Hall, Randy A.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2017
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5465494/
https://ncbi.nlm.nih.gov/pubmed/28424266
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M117.780551
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