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Structure and energetics of pairwise interactions between proteasome subunits RPN2, RPN13, and ubiquitin clarify a substrate recruitment mechanism

The 26S proteasome is a large cellular assembly that mediates the selective degradation of proteins in the nucleus and cytosol and is an established target for anticancer therapeutics. Protein substrates are typically targeted to the proteasome through modification with a polyubiquitin chain, which...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: VanderLinden, Ryan T., Hemmis, Casey W., Yao, Tingting, Robinson, Howard, Hill, Christopher P.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5465478/
https://ncbi.nlm.nih.gov/pubmed/28442575
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M117.785287
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