Gene conversion and evolution of Xq28 duplicons involved in recurring inversions causing severe hemophilia A
Inversions breaking the 1041 bp int1h-1 or the 9.5-kb int22h-1 sequence of the F8 gene cause hemophilia A in 1/30,000 males. These inversions are due to homologous recombination between the above sequences and their inverted copies on the same DNA molecule, respectively, int1h-2 and int22h-2 or int2...
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| Publicado no: | Genome Res |
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| Principais autores: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Cold Spring Harbor Laboratory Press
2005
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC546521/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/15687285/ https://ncbi.nlm.nih.govhttps://doi.org/10.1101/gr.2946205 |
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