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Penfluridol suppresses glioblastoma tumor growth by Akt-mediated inhibition of GLI1

Glioblastoma (GBM) is the most common brain tumor with poor survival rate. Our results show that penfluridol, an antipsychotic drug significantly reduced the survival of ten adult and pediatric glioblastoma cell lines with IC(50) ranging 2–5 μM after 72 hours of treatment and induced apoptosis. Penf...

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Bibliografski detalji
Izdano u:Oncotarget
Glavni autori: Ranjan, Alok, Srivastava, Sanjay K.
Format: Artigo
Jezik:Inglês
Izdano: Impact Journals LLC 2017
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5464842/
https://ncbi.nlm.nih.gov/pubmed/28380428
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.16515
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