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Construction of an immunotoxin, HN3-mPE24, targeting glypican-3 for liver cancer therapy
Glypican-3 (GPC3) is overexpressed in hepatocellular carcinoma (HCC). We constructed a recombinant immunotoxin, HN3-mPE24, which contains a truncated form of Pseudomonas exotoxin A. The toxin portion lacks most of domain II and has seven point mutations in domain III to remove the B-cell epitopes th...
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| Pubblicato in: | Oncotarget |
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| Autori principali: | , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Impact Journals LLC
2016
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5464801/ https://ncbi.nlm.nih.gov/pubmed/27419635 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.10592 |
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