Caricamento...

Immunotoxin targeting glypican-3 regresses liver cancer via dual inhibition of Wnt signaling and protein synthesis

Glypican-3 is a cell surface glycoprotein that associates with Wnt in liver cancer. We develop two antibodies targeting glypican-3, HN3 and YP7. The first antibody recognizes a functional epitope and inhibits Wnt signaling, whereas the second antibody recognizes a C-terminal epitope but does not inh...

Descrizione completa

Salvato in:
Dettagli Bibliografici
Pubblicato in:Nat Commun
Autori principali: Gao, Wei, Tang, Zhewei, Zhang, Yifan, Feng, Mingqian, Qian, Min, Dimitrov, Dimiter S., Ho, Mitchell
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2015
Soggetti:
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4357278/
https://ncbi.nlm.nih.gov/pubmed/25758784
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms7536
Tags: Aggiungi Tag
Nessun Tag, puoi essere il primo ad aggiungerne! !