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Rap1b is required for normal platelet function and hemostasis in mice
Rap1b, an abundant small GTPase in platelets, becomes rapidly activated upon stimulation with agonists. Though it has been implicated to act downstream from G protein–coupled receptors (GPCRs) and upstream of integrin α(IIb)β(3), the precise role of Rap1b in platelet function has been elusive. Here...
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| Autori principali: | , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
American Society for Clinical Investigation
2005
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC546455/ https://ncbi.nlm.nih.gov/pubmed/15696195 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI200522973 |
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