A brain-penetrant RAF dimer antagonist for the noncanonical BRAF oncoprotein of pediatric low-grade astrocytomas

BACKGROUND. Activating mutations or structural rearrangements in BRAF are identified in roughly 75% of all pediatric low-grade astrocytomas (PLGAs). However, first-generation RAF inhibitors approved for adult melanoma have poor blood–brain penetrance and are only effective on tumors that express the...

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Detalhes bibliográficos
Publicado no:Neuro Oncol
Main Authors: Sun, Yu, Alberta, John A., Pilarz, Catherine, Calligaris, David, Chadwick, Emily J., Ramkissoon, Shakti H., Ramkissoon, Lori A., Garcia, Veronica Matia, Mazzola, Emanuele, Goumnerova, Liliana, Kane, Michael, Yao, Zhan, Kieran, Mark W., Ligon, Keith L., Hahn, William C., Garraway, Levi A., Rosen, Neal, Gray, Nathanael S., Agar, Nathalie Y., Buhrlage, Sara J., Segal, Rosalind A., Stiles, Charles D.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2017
Assuntos:
Basic and Translational Investigations
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5464455/
https://ncbi.nlm.nih.gov/pubmed/28082416
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/now261
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