A brain-penetrant RAF dimer antagonist for the noncanonical BRAF oncoprotein of pediatric low-grade astrocytomas

BACKGROUND. Activating mutations or structural rearrangements in BRAF are identified in roughly 75% of all pediatric low-grade astrocytomas (PLGAs). However, first-generation RAF inhibitors approved for adult melanoma have poor blood–brain penetrance and are only effective on tumors that express the...

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Detaylı Bibliyografya
Yayımlandı:Neuro Oncol
Asıl Yazarlar: Sun, Yu, Alberta, John A., Pilarz, Catherine, Calligaris, David, Chadwick, Emily J., Ramkissoon, Shakti H., Ramkissoon, Lori A., Garcia, Veronica Matia, Mazzola, Emanuele, Goumnerova, Liliana, Kane, Michael, Yao, Zhan, Kieran, Mark W., Ligon, Keith L., Hahn, William C., Garraway, Levi A., Rosen, Neal, Gray, Nathanael S., Agar, Nathalie Y., Buhrlage, Sara J., Segal, Rosalind A., Stiles, Charles D.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Oxford University Press 2017
Konular:
Basic and Translational Investigations
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC5464455/
https://ncbi.nlm.nih.gov/pubmed/28082416
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/now261
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