5′ CArG degeneracy in smooth muscle α-actin is required for injury-induced gene suppression in vivo

CC(A/T)(6)GG–dependent (CArG-dependent) and serum response factor–dependent (SRF-dependent) mechanisms are required for gene expression in smooth muscle cells (SMCs). However, an unusual feature of many SMC-selective promoter CArG elements is that they contain a conserved single G or C substitution...

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Hauptverfasser: Hendrix, Jennifer A., Wamhoff, Brian R., McDonald, Oliver G., Sinha, Sanjay, Yoshida, Tadashi, Owens, Gary K.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Clinical Investigation 2005
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC546420/
https://ncbi.nlm.nih.gov/pubmed/15690088
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI200522648
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