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OS01.3 mtTERT promoter as a target for treatment of Glioblastoma
Approximately 86% of GBM tumors exhibit mutation at -124 or -146 bases upstream of the ATG start site in the transcription activating promoter region of Human telomerase reverse transcriptase (hTERT). Mutation in the promoter region of hTERT impairs repression, leading to overexpression of hTERT; in...
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| Pubblicato in: | Neuro Oncol |
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| Autori principali: | , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Oxford University Press
2017
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5463702/ https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nox036.002 |
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