IL-6 inhibits upregulation of membrane-bound TGF-beta 1 on CD4+ T cells and blocking IL-6 enhances oral tolerance

Oral administration of antigen induces regulatory T cells that express latent membrane-bound TGF-beta (LAP) and that have been shown to play an important role in the induction of oral tolerance. We developed an in vitro model to study modulation of LAP+ on CD4+ T cells. The combination of anti-CD3 m...

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Detaylı Bibliyografya
Yayımlandı:J Immunol
Asıl Yazarlar: Kuhn, Chantal, Rezende, Rafael Machado, M'Hamdi, Hanane, da Cunha, Andre Pires, Weiner, Howard L.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2016
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC5463579/
https://ncbi.nlm.nih.gov/pubmed/28039301
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1600921
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