Mutational Signatures Are Critical for Proper Estimation of Purifying Selection Pressures in Cancer Somatic Mutation Data When Using the dN/dS Metric

Large cancer genome sequencing initiatives have led to the identification of cancer driver genes based on signals of positive selection in somatic mutation data. Additionally, the identification of purifying (negative) selection has the potential to identify essential genes that may be of therapeuti...

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Bibliographic Details
Published in:Front Genet
Main Authors: Van den Eynden, Jimmy, Larsson, Erik
Format: Artigo
Language:Inglês
Published: Frontiers Media S.A. 2017
Subjects:
Genetics
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5462936/
https://ncbi.nlm.nih.gov/pubmed/28642787
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fgene.2017.00074
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