TGF-β-induced hepatocyte lincRNA-p21 contributes to liver fibrosis in mice

Hepatocyte death, as well as the following inflammatory and fibrogenic signaling cascades, is the key trigger of liver fibrosis. Here, we isolated hepatocytes from CCl(4)-induced fibrotic liver and found that hepatocyte lincRNA-p21 significantly increased during liver fibrosis. The increase of hepat...

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Vydáno v:Sci Rep
Hlavní autoři: Tu, Xiaolong, Zhang, Yuanyuan, Zheng, Xiuxiu, Deng, Jia, Li, Huanan, Kang, Zhiqian, Cao, Zhipeng, Huang, Zhen, Ding, Zhi, Dong, Lei, Chen, Jiangning, Zang, Yuhui, Zhang, Junfeng
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2017
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5462818/
https://ncbi.nlm.nih.gov/pubmed/28592847
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-03175-0
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