TGF-β-induced hepatocyte lincRNA-p21 contributes to liver fibrosis in mice

Hepatocyte death, as well as the following inflammatory and fibrogenic signaling cascades, is the key trigger of liver fibrosis. Here, we isolated hepatocytes from CCl(4)-induced fibrotic liver and found that hepatocyte lincRNA-p21 significantly increased during liver fibrosis. The increase of hepat...

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Bibliografske podrobnosti
izdano v:Sci Rep
Main Authors: Tu, Xiaolong, Zhang, Yuanyuan, Zheng, Xiuxiu, Deng, Jia, Li, Huanan, Kang, Zhiqian, Cao, Zhipeng, Huang, Zhen, Ding, Zhi, Dong, Lei, Chen, Jiangning, Zang, Yuhui, Zhang, Junfeng
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group UK 2017
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5462818/
https://ncbi.nlm.nih.gov/pubmed/28592847
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-03175-0
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