Increased circulating levels and salivary gland expression of interleukin-18 in patients with Sjögren's syndrome: relationship with autoantibody production and lymphoid organization of the periductal inflammatory infiltrate

IL-18, an immunoregulatory and proinflammatory cytokine, has been shown to play an important pathogenic role in Th1-driven autoimmune disorders. In this study, we evaluated the circulating levels and salivary-gland expression of IL-18 in patients with Sjögren's syndrome (SS), a mainly Th1-media...

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Detalhes bibliográficos
Main Authors: Bombardieri, Michele, Barone, Francesca, Pittoni, Valerio, Alessandri, Cristiano, Conigliaro, Paola, Blades, Mark C, Priori, Roberta, McInnes, Iain B, Valesini, Guido, Pitzalis, Costantino
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2004
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC546280/
https://ncbi.nlm.nih.gov/pubmed/15380044
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/ar1209
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