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Cetuximab Prevents Methotrexate-Induced Cytotoxicity in Vitro through Epidermal Growth Factor Dependent Regulation of Renal Drug Transporters

[Image: see text] The combination of methotrexate with epidermal growth factor receptor (EGFR) recombinant antibody, cetuximab, is currently being investigated in treatment of head and neck carcinoma. As methotrexate is cleared by renal excretion, we studied the effect of cetuximab on renal methotre...

תיאור מלא

שמור ב:
מידע ביבליוגרפי
הוצא לאור ב:Mol Pharm
Main Authors: Caetano-Pinto, Pedro, Jamalpoor, Amer, Ham, Janneke, Goumenou, Anastasia, Mommersteeg, Monique, Pijnenburg, Dirk, Ruijtenbeek, Rob, Sanchez-Romero, Natalia, van Zelst, Bertrand, Heil, Sandra G., Jansen, Jitske, Wilmer, Martijn J., van Herpen, Carla M. L., Masereeuw, Rosalinde
פורמט: Artigo
שפה:Inglês
יצא לאור: American Chemical Society 2017
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC5462489/
https://ncbi.nlm.nih.gov/pubmed/28493713
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.molpharmaceut.7b00308
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