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Tautomeric stabilities of 4-fluorohistidine shed new light on mechanistic experiments with labeled ribonuclease A

Ribonuclease A is the oldest model for studying enzymatic mechanisms, yet questions remain about proton transfer within the active site. Seminal work by Jackson et al. (Science, 1994) labeled Ribonuclease A with 4-fluorohistidine, concluding that active-site histidines act as general acids and bases...

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書目詳細資料
發表在:Chem Phys Lett
Main Authors: Kasireddy, Chandana, Ellis, Jonathan M., Bann, James G., Mitchell-Koch, Katie R.
格式: Artigo
語言:Inglês
出版: 2016
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC5461937/
https://ncbi.nlm.nih.gov/pubmed/28603294
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cplett.2016.10.072
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