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A point mutation at tyrosine-809 in the human colony-stimulating factor 1 receptor impairs mitogenesis without abrogating tyrosine kinase activity, association with phosphatidylinositol 3-kinase, or induction of c-fos and junB genes.

Substitution of phenylalanine for tyrosine-809 in the human colony-stimulating factor 1 receptor (CSF-1R) inhibited its ability to transduce ligand-dependent mitogenic signals in mouse NIH 3T3 cells. When combined with an "activating" mutation at codon 301 that induces constitutive CSF-1R tyrosine k...

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Uloženo v:
Vydáno v:Proc Natl Acad Sci U S A
Hlavní autoři: Roussel, M F, Shurtleff, S A, Downing, J R, Sherr, C J
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 1990
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC54612/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2168557/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.87.17.6738
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