Salsalate ameliorates metabolic disturbances by reducing inflammation in spontaneously hypertensive rats expressing human C-reactive protein and by activating brown adipose tissue in nontransgenic controls

Chronic low-grade inflammation plays an important role in the pathogenesis of insulin resistance. In the current study, we tested the effects of salsalate, a non-steroidal anti-inflammatory drug, in an animal model of inflammation and metabolic syndrome using spontaneously hypertensive rats (SHR) th...

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Publicat a:PLoS One
Autors principals: Trnovská, Jaroslava, Šilhavý, Jan, Kuda, Ondřej, Landa, Vladimír, Zídek, Václav, Mlejnek, Petr, Šimáková, Miroslava, Strnad, Hynek, Škop, Vojtěch, Oliyarnyk, Olena, Kazdová, Ludmila, Haluzík, Martin, Pravenec, Michal
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2017
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5460879/
https://ncbi.nlm.nih.gov/pubmed/28586387
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0179063
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