Fumaric Acid Esters Can Block Pro-Inflammatory Actions of Human CRP and Ameliorate Metabolic Disturbances in Transgenic Spontaneously Hypertensive Rats

Inflammation and oxidative stress have been implicated in the pathogenesis of metabolic disturbances. Esters of fumaric acid, mainly dimethyl fumarate, exhibit immunomodulatory, anti-inflammatory, and anti-oxidative effects. In the current study, we tested the hypothesis that fumaric acid ester (FAE...

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Detalhes bibliográficos
Main Authors: Šilhavý, Jan, Zídek, Václav, Mlejnek, Petr, Landa, Vladimír, Šimáková, Miroslava, Strnad, Hynek, Oliyarnyk, Olena, Škop, Vojtěch, Kazdová, Ludmila, Kurtz, Theodore, Pravenec, Michal
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2014
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4092096/
https://ncbi.nlm.nih.gov/pubmed/25010431
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0101906
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