Fumaric Acid Esters Can Block Pro-Inflammatory Actions of Human CRP and Ameliorate Metabolic Disturbances in Transgenic Spontaneously Hypertensive Rats

Inflammation and oxidative stress have been implicated in the pathogenesis of metabolic disturbances. Esters of fumaric acid, mainly dimethyl fumarate, exhibit immunomodulatory, anti-inflammatory, and anti-oxidative effects. In the current study, we tested the hypothesis that fumaric acid ester (FAE...

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Main Authors: Šilhavý, Jan, Zídek, Václav, Mlejnek, Petr, Landa, Vladimír, Šimáková, Miroslava, Strnad, Hynek, Oliyarnyk, Olena, Škop, Vojtěch, Kazdová, Ludmila, Kurtz, Theodore, Pravenec, Michal
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2014
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4092096/
https://ncbi.nlm.nih.gov/pubmed/25010431
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0101906
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