Sphingosine kinase 1 expression enhances colon tumor growth

BACKGROUND: Accumulating evidence suggests that sphingosine kinase 1 (SphK1)/sphingosine 1-phosphate pathway plays a pivotal role in colon carcinogenesis. METHODS: To further support the evidence, we investigated the effects of SphK1 using three separate animal models: SphK1 knockout mice, SphK1 ove...

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Bibliografske podrobnosti
izdano v:J Transl Med
Main Authors: Furuya, Hideki, Shimizu, Yoshiko, Tamashiro, Paulette M., Iino, Kayoko, Bielawski, Jacek, Chan, Owen T. M., Pagano, Ian, Kawamori, Toshihiko
Format: Artigo
Jezik:Inglês
Izdano: BioMed Central 2017
Teme:
Research
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5460497/
https://ncbi.nlm.nih.gov/pubmed/28583134
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12967-017-1220-x
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