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Candida albicans Sap6 amyloid regions function in cellular aggregation and zinc binding, and contribute to zinc acquisition

Candida albicans is an opportunistic fungal pathogen colonizing the oral cavity. C. albicans secreted aspartic protease Sap6 is important for virulence during oral candidiasis since it degrades host tissues to release nutrients and essential transition metals. We found that zinc specifically increas...

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Bibliografske podrobnosti
izdano v:Sci Rep
Main Authors: Kumar, Rohitashw, Breindel, Christine, Saraswat, Darpan, Cullen, Paul J., Edgerton, Mira
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group UK 2017
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5460171/
https://ncbi.nlm.nih.gov/pubmed/28588252
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-03082-4
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