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Systematic discovery of mutation-specific synthetic lethals by mining pan-cancer human primary tumor data
Two genes are synthetically lethal (SL) when defects in both are lethal to a cell but a single defect is non-lethal. SL partners of cancer mutations are of great interest as pharmacological targets; however, identifying them by cell line-based methods is challenging. Here we develop MiSL (Mining Syn...
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| Publicado no: | Nat Commun |
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| Main Authors: | , , , , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5460027/ https://ncbi.nlm.nih.gov/pubmed/28561042 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms15580 |
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