A promoter-proximal transcript targeted by genetic polymorphism controls E-cadherin silencing in human cancers

Long noncoding RNAs are emerging players in the epigenetic machinery with key roles in development and diseases. Here we uncover a complex network comprising a promoter-associated noncoding RNA (paRNA), microRNA and epigenetic regulators that controls transcription of the tumour suppressor E-cadheri...

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Publicado en:Nat Commun
Autores principales: Pisignano, Giuseppina, Napoli, Sara, Magistri, Marco, Mapelli, Sarah N., Pastori, Chiara, Di Marco, Stefano, Civenni, Gianluca, Albino, Domenico, Enriquez, Claudia, Allegrini, Sara, Mitra, Abhishek, D'Ambrosio, Gioacchino, Mello-Grand, Maurizia, Chiorino, Giovanna, Garcia-Escudero, Ramon, Varani, Gabriele, Carbone, Giuseppina M., Catapano, Carlo V.
Formato: Artigo
Lenguaje:Inglês
Publicado: Nature Publishing Group 2017
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5459991/
https://ncbi.nlm.nih.gov/pubmed/28555645
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms15622
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