MicroRNA-424 impairs ubiquitination to activate STAT3 and promote prostate tumor progression

Mutations and deletions in components of ubiquitin ligase complexes that lead to alterations in protein turnover are important mechanisms in driving tumorigenesis. Here we describe an alternative mechanism involving upregulation of the microRNA miR-424 that leads to impaired ubiquitination and degra...

Ful tanımlama

Kaydedildi:
Detaylı Bibliyografya
Yayımlandı:J Clin Invest
Asıl Yazarlar: Dallavalle, Cecilia, Albino, Domenico, Civenni, Gianluca, Merulla, Jessica, Ostano, Paola, Mello-Grand, Maurizia, Rossi, Simona, Losa, Marco, D’Ambrosio, Gioacchino, Sessa, Fausto, Thalmann, George N., Garcia-Escudero, Ramon, Zitella, Andrea, Chiorino, Giovanna, Catapano, Carlo V., Carbone, Giuseppina M.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Society for Clinical Investigation 2016
Konular:
Research Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC5127674/
https://ncbi.nlm.nih.gov/pubmed/27820701
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI86505
Etiketler: Etiketle
Etiket eklenmemiş, İlk siz ekleyin!

Benzer Materyaller