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Promoter-specific transcriptional interference and c-myc gene silencing by siRNAs in human cells
Small interfering RNAs (siRNAs) directed to gene promoters can silence genes at the transcriptional level. siRNA-directed transcriptional silencing (RdTS) was first described in plants and yeasts and more recently in mammalian cells. RdTS has been associated with the induction of epigenetic changes...
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| Main Authors: | , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Nature Publishing Group
2009
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2699364/ https://ncbi.nlm.nih.gov/pubmed/19461583 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2009.139 |
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