Attenuation of Inhibitory Prostaglandin E2 Signaling in Human Lung Fibroblasts Is Mediated by Phosphodiesterase 4

The etiology of chronic obstructive pulmonary disease (COPD) is complex and involves an aberrant inflammatory response. Prostaglandin (PG)E2 is elevated in COPD, is a key modulator of lung fibroblast functions, and may influence COPD progression. Most studies evaluating the effects of PGE2 on lung f...

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Detalhes bibliográficos
Publicado no:Am J Respir Cell Mol Biol
Main Authors: Michalski, Joel, Kanaji, Nobuhiro, Liu, Xiangde, Nogel, Steve, Wang, Xingqi, Basma, Hesham, Nakanishi, Masanori, Sato, Tadashi, Gunji, Yoko, Fahrid, Maha, Nelson, Amy, Muller, Kai-Christian, Holz, Olaf, Magnussen, Helgo, Rabe, Klaus F., Toews, Myron L., Rennard, Stephen I.
Formato: Artigo
Idioma:Inglês
Publicado em: American Thoracic Society 2012
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5459525/
https://ncbi.nlm.nih.gov/pubmed/23043089
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1165/rcmb.2012-0057OC
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