Antibody remodeling: a general solution to the design of a metal-coordination site in an antibody binding pocket.

To develop a general approach to designing cofactor-binding sites for catalytic antibodies, we characterized structural patterns in the binding sites of antibodies and zinc enzymes. Superposition of eight sets of antibody light- and heavy-chain variable domains identified structurally conserved site...

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Bibliografiske detaljer
Main Authors: Roberts, V A, Iverson, B L, Iverson, S A, Benkovic, S J, Lerner, R A, Getzoff, E D, Tainer, J A
Format: Artigo
Sprog:Inglês
Udgivet: 1990
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC54595/
https://ncbi.nlm.nih.gov/pubmed/2395868
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