In silico discovery of substituted pyrido[2,3-d]pyrimidines and pentamidine-like compounds with biological activity in myotonic dystrophy models

Myotonic dystrophy type 1 (DM1) is a rare multisystemic disorder associated with an expansion of CUG repeats in mutant DMPK (dystrophia myotonica protein kinase) transcripts; the main effect of these expansions is the induction of pre-mRNA splicing defects by sequestering muscleblind-like family pro...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: González, Àlex L., Konieczny, Piotr, Llamusi, Beatriz, Delgado-Pinar, Estefanía, Borrell, José I., Teixidó, Jordi, García-España, Enrique, Pérez-Alonso, Manuel, Estrada-Tejedor, Roger, Artero, Rubén
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2017
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5459475/
https://ncbi.nlm.nih.gov/pubmed/28582438
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0178931
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