Structure-based design of nonpeptide inhibitors specific for the human immunodeficiency virus 1 protease.

By using a structure-based computer-assisted search, we have found a butyrophenone derivative that is a selective inhibitor of the human immunodeficiency virus 1 (HIV-1) protease. The computer program creates a negative image of the active site cavity using the crystal structure of the HIV-1 proteas...

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Detalhes bibliográficos
Main Authors: DesJarlais, R L, Seibel, G L, Kuntz, I D, Furth, P S, Alvarez, J C, Ortiz de Montellano, P R, DeCamp, D L, Babé, L M, Craik, C S
Formato: Artigo
Idioma:Inglês
Publicado em: 1990
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC54593/
https://ncbi.nlm.nih.gov/pubmed/2204060
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